Since having a tablet things weren't the same. Of course waving a stylus won't make a Vermeer out of you but is sure speeds things up !
The feel and infinite variations you can do with a brush on real canvas is, to me, not even remotely equaled by technology. But we're getting there.

I don't have any tile based art here anymore but I've been asked for some early 16 system colours works as well as ANSI art.